gossypol: from contraceptive for men to antitumoral activity
نویسندگان
چکیده
it is widely thought that bcl-2 family proteins regulate commitment to apoptosis primarily through their capacity to control the permeability of the mitochondrial outer membrane permeabilization (momp) triggers the release of multiple apoptogenic factors into the cytosol and, thereby apoptosis. various bcl-2 family members affect this key event of the apoptotic cascade in different ways, determining their pro- or anti-apoptotic status. the bcl-2-type proteins inhibit momp, thereby preserving cell viability. in contrast, bax-type proteins and the diverse group of bh3-only proteins facilitate momp and thus promote cell death. recently, several drugs that act as bh3 mimetics have been identified, including gossypol. this review revisits the proprieties of gossypol family, their using as anticancer agents for cancer therapy.
منابع مشابه
Current contraceptive choices for men?
Though many contraceptives are female-directed, both men and women share equal responsibility for contraception! Unfortunately, the list of currently available male-directed contraceptive options is significantly smaller; methods include external (male) condoms, vasectomy, and withdrawal (a.k.a. "pulling out"). When picking the best contraceptive fit, there are some factors to consider about each.
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عنوان ژورنال:
gastroenterology and hepatology from bed to benchجلد ۲۰۰۹، شماره ۰۷، صفحات ۰-۰
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